Liver-specific loss of the transcriptional coregulator ARGLU1 protects against diet-induced obesity in mice through decreased lipid absorption
Sarah B. Cash, Michael Fadi Saikali, Lilia Magomedova, Sarah A. Shawky, Fatemeh Molaei, Jin Shi, Pierre E. Thibeault, Sulayman Aslan Lyons, Candice Kwok, Taira Kiyota, Stéphane Angers, Ahmed M. Aman, Jacqueline Leah Beaudry, Carolyn L. Cummins
This study shows that liver-specific loss of ARGLU1 in mice prevents diet-induced obesity without affecting food intake, locomotion, or energy expenditure, due to reduced lipid absorption and altered bile acid metabolism.
bioRxiv · Feb 5, 2026 · PreprintPhysiology