Ahmed M. Aman

This study develops a mouse model of pediatric gliomas and identifies BRAF and MAPK signaling as critical drivers of tumor progression and therapeutic resistance.

This study shows that liver-specific loss of ARGLU1 in mice prevents diet-induced obesity without affecting food intake, locomotion, or energy expenditure, due to reduced lipid absorption and altered bile acid metabolism.

This study identifies DNA-PK as a synthetic lethal target in TP53-deficient SHH medulloblastoma, showing that inhibiting DNA-PK enhances radiosensitivity and improves survival in preclinical models.

The paper identifies first-in-class inhibitors (BLUEs) that selectively inhibit BRISC complex activity by stabilizing an autoinhibited dimer, reducing interferon-stimulated gene expression.