Spontaneous Axonal ER Ca2+ Waves Mediate a Shift From Action Potential-Dependent to Independent Glutamate Release in the YAC128 HD-Model
James P. Mackay, Amy Smith-Dijak, Ellen T. Koch, Peng Zhang, Evan Fung, Wissam B. Nassrallah, Caodu Buren, Mandi E. Schmidt, Michael R. Hayden, Lynn A. Raymond
The paper shows that spontaneous axonal ER Ca2+ waves increase miniature glutamate release while reducing AP-dependent release in YAC128 HD-model neurons.
bioRxiv · Jan 31, 2020 · PreprintNeuroscience