Lynn A. Raymond

This study uses mesoscale calcium imaging in HD mice during a sensory-guided task to explore altered cortical activity and its behavioral implications.

This study shows that JZL184 improves motor learning and striatal plasticity in YAC128 HD mice by increasing 2-AG levels, suggesting endocannabinoid modulation as a potential therapeutic target for HD.

This study uses a water-reaching task to identify early forelimb motor deficits and cortical activity changes in Huntington Disease mouse models.

This study examines altered cortical processing of sensory input in Huntington disease mouse models, finding increased LFP power and sensory signal spread in HD mice.

This paper introduces an automated behavioural testing system to assess motor learning in Huntington disease mice and identifies impaired kinematic variability modulation as a specific deficit.

This study shows Zdhhc5 is essential for forming excitatory synapses and its loss leads to synaptic deficits in mice.

The paper shows that spontaneous axonal ER Ca2+ waves increase miniature glutamate release while reducing AP-dependent release in YAC128 HD-model neurons.