Astrocytes control the Neuroinflammation and ILC2 response through IL-33/ST2 signaling, during protection against Cerebral Malaria in Toxoplasma-P. berghei coinfected Mice
Inès Leleu, Tarun Keswani, Fabien Herbert, Capucine Picavet, Manon Arnaud, Sabrina Marion, Corine Glineur, Sylviane Pied
This study shows that Toxoplasma gondii brain infection protects against cerebral malaria in mice by altering astrocyte reactivity and activating the IL-33/ST2 pathway to recruit ILC2 cells.
bioRxiv · Oct 24, 2025 · PreprintImmunology