Conformational and Functional Regulation of SET by Legumain Cleavage
Carina Horak, Alexander C. Wieland, Rupert Klaushofer, Peter Briza, Hans Brandstetter, Elfriede Dall
This study shows legumain cleaves SET at two sites, forming a stable complex and impairing its interaction with histone 1, while also abolishing SET's positive modulation of PP2A activity.
Journal of Molecular Biology · Apr 5, 2025Peer-reviewedMolecular Biology