Transcriptional output, cell types densities and normalization in spatial transcriptomics
Manuel Saiselet, Joel Rodrigues Vitória, Adrien Tourneur, Ligia Craciun, Alex Spinette, Denis Larsimont, Guy Andry, Joakim Lundeberg, Carine Maenhaut, Vincent Detours
The paper shows that total read counts in spatial transcriptomics spots reflect cell numbers and biology, and that normalization by total read counts can distort cell-type-related expression.
Journal of Molecular Cell Biology · Jun 15, 2020Peer-reviewedGenomics