Vincent Detours

The paper quantifies parental mutation burden symmetry in human cancers using PhaSoMix, finding near-equal mutation accumulation between maternal and paternal genomes.

This study uses single nuclei RNA-seq and spatial transcriptomics to analyze transcriptional patterns in papillary and anaplastic thyroid cancers, revealing idiosyncratic and generic transcriptional variations and EMT-related features.

The paper builds a histological atlas using computational methods and the GTEx dataset, revealing how age, sex, genetics, and sub-clinical pathologies influence tissue structures across 40 organs.

The paper develops a 16-gene signature (MG-GEM) that predicts survival benefit from adjuvant gemcitabine in resectable pancreatic cancer based on glycation stress, outperforming existing signatures.

This study shows that combining FOLFIRINOX with stereotactic body radiotherapy remodels pancreatic ductal adenocarcinoma, improving stromal and metabolic features and prognosis.

This study generates transplantable human thyroid organoids from embryonic stem cells that restore thyroid hormone levels in athyreotic mice.

The paper uses single-cell transcriptomics to reveal heterogeneity in zebrafish thyroid thyrocytes and characterizes surrounding cell types.

The paper shows that total read counts in spatial transcriptomics spots reflect cell numbers and biology, and that normalization by total read counts can distort cell-type-related expression.

The paper identifies hominin-specific NOTCH2 paralogs that enhance human cortical neurogenesis by modulating Delta/Notch interactions.

This study identifies ADAR expression and inflammation as key regulators of A-to-I RNA editing in breast cancer, showing increased editing frequency in tumors and its impact on cell proliferation and apoptosis.

The paper critiques a study claiming cancer risk is mainly due to random mutations, highlighting overlooked preventable cases in specific risk groups.