GenomicsJournal of Molecular Cell BiologyPeer-reviewed
Transcriptional output, cell types densities and normalization in spatial transcriptomics
Manuel Saiselet, Joel Rodrigues Vitória, Adrien Tourneur…·Vincent Detours
The paper shows that total read counts in spatial transcriptomics spots reflect cell numbers and biology, and that normalization by total read counts can distort cell-type-related expression.