Multitrait genetic-phenotype associations to connect disease variants and biological mechanisms
Hanna Julienne, Vincent Laville, Zachary Ryan McCaw, Zihuai He, Vincent Guillemot, Carla Lasry, Andrey Ziyatdinov, Amaury Vaysse, Pierre Lechat, Hervé Ménager, Wilfried Le Goff, Marie‐Pierre Dubé, Peter Kraft, Iuliana Ionita‐Laza, Bjarni Jóhann Vilhjálmsson, Hugues Aschard
The paper decomposes multitrait genetic associations to identify pleiotropy profiles linking SNPs to biological pathways and drug targets.
bioRxiv · Jun 26, 2020 · PreprintGenetics