Amaury Vaysse

This study shows that T cell engagers induce endogenous vaccination by triggering a cytotoxic wave and cross-priming of CD8 T cells via dendritic cells.

This study identifies FANCM-RMI1/2 as a driver of PARP inhibitor sensitivity in BRCA2-deficient cells, revealing distinct adaptation mechanisms between BRCA1 and BRCA2 loss.

This study shows CAR-macrophages can activate anti-tumor T cells without phagocytosis, highlighting cytokine and chemokine signaling as key drivers.

This study shows that the E. coli CNF1 toxin reprograms intestinal stem cells in organoids to a fetal-like state, inducing a serrated colorectal cancer transcriptional signature.

This study identifies poor prognosis in IBD-related colon cancer due to gut dysbiosis and immune response failure, linked to microbial imbalance and altered gene expression.

This study identifies common genetic risk loci for hematopoietic cancers in dogs and humans by combining GWAS, sequencing, and imputation across breeds and cancers.

The paper decomposes multitrait genetic associations to identify pleiotropy profiles linking SNPs to biological pathways and drug targets.

The paper uses admixture mapping to identify smoking-dependent loci affecting lung function in African Americans, finding two genome-wide significant loci associated with ancestry-smoking interactions.

This study identifies 588 SNP-metabolite associations using the METSIM cohort, revealing pleiotropy, temporal changes, and age-related genetic control shifts.