This study identifies miR-100-5p as a regulator of postprandial triglyceride response by targeting PCSK9, suggesting its potential as a biomarker for cardiovascular risk.

Atherosclerosis · Aug 1, 2026Peer-reviewedPhysiology

REGULATION OF HDL DYSFUNCTIONALITY BY PHOSPHATIDYLETHANOLAMINE LINKS POLY-UNSATURATED FATTY ACIDS WITH ATHEROSCLEROTIC CARDIOVASCULAR DISEASES

Malik Taradeh, Lise M. Hardy, Veronica D. Dahik, Marie Lhomme, Hua Wang, Canelle Reydellet, Clément Materne, Pukar KC, Eric Bun, Maud Clemessy, Jean-Paul Paı̈s de Barros, Sophie Galier, Éric Frisdal, Hervé Durand, Maharajah Ponnaiah, , Wilfried Le Goff

This study shows that arachidonic acid-containing phosphatidylethanolamine (ARA-PE) impairs HDL function, promoting atherosclerosis, while eicosapentaenoic acid-PE (EPA-PE) restores HDL function and may reduce ASCVD risk.

bioRxiv · May 27, 2025 · PreprintCell Biology

Enhancer/gene relationships: need for more reliable genome-wide reference sets

Tristan Hoellinger, Camille Mestre, Hugues Aschard, Wilfried Le Goff, Sylvain Foissac, Thomas Faraut, Sarah Djebali

The paper evaluates two functional link methods for identifying enhancer/gene relationships using benchmark data and finds neither performs best, highlighting the need for reliable genome-wide reference data.

Frontiers in Bioinformatics · Feb 24, 2023Peer-reviewedBioinformatics

Multitrait genetic-phenotype associations to connect disease variants and biological mechanisms

Hanna Julienne, Vincent Laville, Zachary Ryan McCaw, Zihuai He, Vincent Guillemot, Carla Lasry, Andrey Ziyatdinov, Amaury Vaysse, Pierre Lechat, Hervé Ménager, Wilfried Le Goff, Marie‐Pierre Dubé, Peter Kraft, Iuliana Ionita‐Laza, Bjarni Jóhann Vilhjálmsson, Hugues Aschard

The paper decomposes multitrait genetic associations to identify pleiotropy profiles linking SNPs to biological pathways and drug targets.

bioRxiv · Jun 26, 2020 · PreprintGenetics