Marie‐Pierre Dubé

This study shows that CETP isoforms influence human traits, particularly in pituitary and thyroid glands, and reveals tissue-specific CVD associations and epistatic interactions involving ADCY9.

This study identifies 80 genetic loci and 61 effector genes associated with dilated cardiomyopathy through GWAS and integrates transcriptomic data to uncover biological pathways and cellular states involved in the disease.

This study identifies seven genes associated with heart failure progression using exome sequencing in 8,089 patients and prioritizes them for therapeutic target validation.

This study examines how sex and BMI modify the effect of genetically predicted lower CETP levels on lipid biomarkers and cardiovascular outcomes using observational genetic data.

This study identifies 667 genetic loci associated with lipid species and links 186 of them to coronary artery disease through integrative lipidomics and genomics.

ExPheWas provides a web-based browser to explore gene-phenotype associations from a pheWAS study in the UK Biobank, identifying potential disease-related genes like MYOT for atrial fibrillation.

The paper identifies a sex-specific evolutionary interaction between ADCY9 and CETP variants associated with dalcetrapib response and cardiovascular traits.

The paper decomposes multitrait genetic associations to identify pleiotropy profiles linking SNPs to biological pathways and drug targets.

This study identifies tissue-specific RNA expression of integrated HHV-6A/B in vivo and links it to increased antibody responses against specific viral antigens.

This study validates two genome-wide polygenic risk scores for coronary artery disease in French Canadians, showing good performance for prevalent CAD but limited utility for incident and recurrent CAD.

This study identifies 15 common and 9 low-frequency protein-coding variants associated with body fat distribution, implicating novel genes related to lipid homeostasis and type 2 diabetes.