Author

Carla Lourens

Amsterdam University Medical Centers

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Biology Disciplines

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Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:Bayesian inference· 1

Frequent Co-Authors

Aartjan J.W. te VelthuisiD· 1 shared Alan S. PerelsoniD· 1 shared Bjarke Frost NielseniD· 1 shared Bryan Thomas GrenfelliD· 1 shared Simon LeviniD· 1 shared Yimei LiiD· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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6 top collaborators · 15 mutual co-author links

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1 shared paperMicrobiology

Aartjan J.W. te VelthuisORCID

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1 paper

Recent·Most cited

Defective Viral Genomes Reveal History-dependent Self-regulation of Type I Interferon Dynamics

Yimei Li, Carla Lourens, Bjarke Frost Nielsen, Simon Levin, Alan S. Perelson, Bryan Thomas Grenfell, Aartjan J.W. te Velthuis

The paper develops a Bayesian model to show that defective viral genomes modulate type I interferon dynamics by both inducing and suppressing IFN through cumulative exposure, explaining how pandemic viruses evade innate immunity.

bioRxiv · Oct 31, 2026 · PreprintMicrobiology