Juvenile reinstatement of TCF4 in Pitt-Hopkins syndrome model mice reveals a critical window for genetic intervention
Lucas M. James, Carlee A. Friar, Siyuan Liang, Eric B. Gao, Alain. C Burette, Benjamin D. Philpot
This study shows that restoring TCF4 in juvenile PTHS model mice only partially reverses behavioral phenotypes, highlighting a critical early window for effective treatment.
bioRxiv · Dec 24, 2025 · PreprintNeuroscience