Author

Lucas M. James

University of North Carolina at Chapel HillORCID 0000-0003-0499-9299Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Genomics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:mouse· 3 Research Focus:differential expression· 2 Research Focus:cell type annotation· 1 Assay:CRISPR screen· 1 Assay:electronic health records· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1

Frequent Co-Authors

Benjamin D. PhilpotiD· 3 shared Alain C. BuretteiD· 1 shared Alain. C Burette· 1 shared Alysson Renato MuotriiD· 1 shared Arthur S. LeeiD· 1 shared Audrey L. SmithiD· 1 shared Beth MartiniD· 1 shared Carlee A. Friar· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 19 mutual co-author links

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3 shared papersNeuroscience

Benjamin D. PhilpotORCID

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3 papers

Recent·Most cited

NeurosciencebioRxivPreprintSep 19, 2026

Parvalbumin interneurons and dentate gyrus homeostatic dysregulation shape epileptogenesis in Angelman syndrome model mice

Nicholas W. Ringelberg, David W Kipp, Renée E. Mayfield…·Benjamin D. Philpot

This study identifies parvalbumin interneurons and dentate gyrus remodeling as key factors in epileptogenesis in Angelman syndrome model mice.

1 citation

mouseelectronic health records

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NeurosciencebioRxivPreprintDec 24, 2025

Juvenile reinstatement of TCF4 in Pitt-Hopkins syndrome model mice reveals a critical window for genetic intervention

Lucas M. James, Carlee A. Friar, Siyuan Liang…·Benjamin D. Philpot

This study shows that restoring TCF4 in juvenile PTHS model mice only partially reverses behavioral phenotypes, highlighting a critical early window for effective treatment.

1 citation

mouseexperimental assay

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GenomicsbioRxivPreprintNov 4, 2025

Large-scale discovery of neural enhancers for cis-regulation therapies

Troy A. McDiarmid, Nicholas F. Page, Florence M. Chardon…·Jay Shendure

The paper identifies active human neural enhancers and CRISPRa gRNAs that upregulate NDD risk genes, providing a resource for cis-regulatory therapy development.

3 citations

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