Loss of DAXX induces alternative lengthening of telomeres (ALT)-associated hallmarks in prostate cancer cells in a context-specific manner
Joakin Mori, Joseph Da, Jiyoung Kim, Anthony J. Rizzo, Christine Davis, Carlo Lanza, Jacqueline A. Brosnan‐Cashman, Alan Keith Meeker, Christopher M. Heaphy, Mindy Kim Graham
This study shows that DAXX mutations induce ALT-associated features in prostate cancer cells, but only in CWR22Rv1 cells, not in LAPC-4 cells.
bioRxiv · Aug 6, 2025 · PreprintCancer Biology