Adaptive nanopore sequencing for single cell characterization of cancer mutations and gene rearrangements
Susan M. Grimes, Heon Seok Kim, Sharmili Roy, Anuja Sathe, Carlos I. Ayala, Alison Figueroa Almeda, Sarah Haebe, Tanaya Shree, Ronald Levy, Billy T. Lau, Hanlee P. Ji
This study develops a single-cell method using nanopore sequencing to identify somatic mutations and gene rearrangements in cancer cells and integrates these with transcriptomes.
bioRxiv · Nov 22, 2022 · PreprintGenomics