Billy T. Lau

Cancer subclone detection based on DNA copy number in single cell and spatial omic sequencing data

Clonalscope detects cancer subclones using DNA copy number data from single-cell and spatial omic sequencing, identifying spatially segregated subclones and validating them with matched scDNA-seq data.

Nanopore-based cell-free DNA fragmentation and methylation profiles from the cerebral spinal fluid of patients with lung cancer brain metastases

This study analyzes DNA fragmentation and methylation in CSF-derived cfDNA from NSCLC-BMET patients and finds distinct patterns compared to controls and plasma-derived cfDNA.

Magnetic DNA random access memory with nanopore readouts and exponentially-scaled combinatorial addressing

This paper introduces MDRAM, a DNA-based random access memory system that enables efficient and scalable readouts using nanopore sequencing and magnetic bead conjugation.

Single molecule methylation profiles of cell-free DNA in cancer with nanopore sequencing

The paper develops a nanopore sequencing strategy to measure cfDNA methylomes in cancer patients, enabling longitudinal monitoring during treatment.

Single cell and spatial alternative splicing analysis with long read sequencing

The paper develops Longcell, a statistical framework for accurate isoform quantification in single cell and spatial long-read sequencing data, revealing intra-cell splicing heterogeneity and validating regulatory targets.

Adaptive nanopore sequencing for single cell characterization of cancer mutations and gene rearrangements

This study develops a single-cell method using nanopore sequencing to identify somatic mutations and gene rearrangements in cancer cells and integrates these with transcriptomes.

Single cell CRISPR base editor engineering and transcriptional characterization of cancer mutations

The paper develops a single-cell CRISPR base editor method to engineer and assess the transcriptional impact of cancer mutations in cell lines.

Single cell multi-omic mapping of subclonal architecture and pathway phenotype in primary gastric and metastatic colon cancers

The paper integrates scDNA-seq and scRNA-seq data to characterize subclonal architecture and pathway activity in gastric and colorectal cancers.

Single cell characterization of CRISPR-modified transcript isoforms with nanopore sequencing

The paper develops a single-cell method combining CRISPR edits and long-read sequencing to characterize transcript isoforms and confirm genomic edits at single-cell resolution.

Alleloscope: Integrative single cell analysis of allele-specific copy number alterations and chromatin accessibility in cancer

Alleloscope analyzes allele-specific copy number and chromatin accessibility in single-cell cancer data, revealing complex copy number events and their role in intratumor heterogeneity.

Joint single cell DNA-Seq and RNA-Seq of gastric cancer reveals subclonal signatures of genomic instability and gene expression

The paper combines single cell DNA-Seq and RNA-Seq in gastric cancer to reveal subclonal genomic instability and gene expression patterns, showing evidence of tumor evolution.

Genetic risk of cholangiocarcinoma is linked to the autophagy gene ATG7

The paper identifies ATG7 as a genetic risk factor for cholangiocarcinoma through germline mutations and population studies, linking autophagy dysfunction to cancer development.

Single-cell transcriptome analysis identifies distinct cell types and intercellular niche signaling in a primary gastric organoid model