Heon Seok Kim

The paper identifies mechanisms by which CRISPR, base editors, and prime editors cause large DNA deletions and proposes strategies to mitigate them.

The paper develops Longcell, a statistical framework for accurate isoform quantification in single cell and spatial long-read sequencing data, revealing intra-cell splicing heterogeneity and validating regulatory targets.

This study develops a single-cell method using nanopore sequencing to identify somatic mutations and gene rearrangements in cancer cells and integrates these with transcriptomes.

The paper develops a single-cell CRISPR base editor method to engineer and assess the transcriptional impact of cancer mutations in cell lines.

The paper develops a single-cell method combining CRISPR edits and long-read sequencing to characterize transcript isoforms and confirm genomic edits at single-cell resolution.

Alleloscope analyzes allele-specific copy number and chromatin accessibility in single-cell cancer data, revealing complex copy number events and their role in intratumor heterogeneity.