An Improved Manufacturing Method for Infusible Extracellular Matrix Materials to Enable Efficient Scale-Up, Improved Efficacy, and Clinical Translation
Michael Nguyen, Emma I Zelus, Maria L Karkanitsa, Benjamin Liebman, Colin Luo, Carlos Munoz, JuanJuan Liu, Connor Conklin, Pedro Cabrales, Mark Hepokoski, Adam Kinsey, Karen L. Christman
This paper introduces a new manufacturing method for infusible extracellular matrix (iECM) using depth filtration and tangential flow filtration (DF-TFF) to improve production efficiency, concentration, and compliance with cGMP standards.
bioRxiv · Nov 2, 2026 · PreprintBioengineering