Karen L. Christman

This paper introduces a new manufacturing method for infusible extracellular matrix (iECM) using depth filtration and tangential flow filtration (DF-TFF) to improve production efficiency, concentration, and compliance with cGMP standards.

This study investigates the effects of different molecular weight components of an intravascularly infusible decellularized extracellular matrix (iECM) on vascular binding and pro-reparative gene expression after myocardial infarction.

This study shows gonadal and chromosomal sex independently and together affect immune responses to implanted scaffolds in mice.

This study uses snRNAseq to identify cell-specific pro-repair responses induced by an infusible ECM biomaterial after myocardial infarction.

This study shows that an infusible extracellular matrix biomaterial improves survival in a mouse model of severe systemic inflammation by reducing inflammation and organ failure.

This study uses spatial and single nucleus transcriptomics to analyze the regional and cell-specific effects of ECM hydrogel treatments in myocardial infarction, revealing differences in immune modulation and cardiac development between subacute and chronic administration.

This paper develops a 3D biomimetic scaffold model to support in vitro lactation by human milk-derived mammary epithelial cells, enabling secretion of beta-casein and milk-fat-globules.

This study develops a light-based bioprinting method using decellularized extracellular matrix to create anisotropic cartilage scaffolds that promote tissue maturation and mimic native structure.