Efficient synthesis of arabinosyl nucleosides via active site engineering of the Leishmania mexicana purine 2'-deoxyribosyltranferase
Davide Agostino Cecchini, Javier Acosta, Laura Pilar Saiz, Carmen Ortega, Pierre Alexandre Kaminski, Jesús Fernández‐Lucas, Aurélio Hidalgo
This paper reports engineered variants of Leishmania mexicana purine deoxyribosyltransferase with enhanced arabinosyltransferase activity for synthesizing vidarabine, without compromising thermal stability.
bioRxiv · Nov 29, 2024 · PreprintBiochemistry