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Laura Pilar Saiz

Centro de Biología Molecular Severo Ochoa

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Aurélio HidalgoiD· 1 shared Carmen Ortega· 1 shared Davide Agostino CecchiniiD· 1 shared Javier AcostaiD· 1 shared Jesús Fernández‐LucasiD· 1 shared Pierre Alexandre KaminskiiD· 1 shared

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Aurélio HidalgoORCID

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BiochemistrybioRxivPreprintNov 29, 2024

Efficient synthesis of arabinosyl nucleosides via active site engineering of the Leishmania mexicana purine 2'-deoxyribosyltranferase

Davide Agostino Cecchini, Javier Acosta, Laura Pilar Saiz…·Aurélio Hidalgo

This paper reports engineered variants of Leishmania mexicana purine deoxyribosyltransferase with enhanced arabinosyltransferase activity for synthesizing vidarabine, without compromising thermal stability.

DOI 10.1101/2024.11.29.626018

experimental assay

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