BiochemistrybioRxivPreprint
Efficient synthesis of arabinosyl nucleosides via active site engineering of the Leishmania mexicana purine 2'-deoxyribosyltranferase
Davide Agostino Cecchini, Javier Acosta, Laura Pilar Saiz…·Aurélio Hidalgo
This paper reports engineered variants of Leishmania mexicana purine deoxyribosyltransferase with enhanced arabinosyltransferase activity for synthesizing vidarabine, without compromising thermal stability.
DOI 10.1101/2024.11.29.626018