Na+/Ca2+ exchanger triggers transient disruption of axon initial segments in hippocampal granule cells after brief ischemia.
Carol Serra, Emma Martínez‐Alonso, María Irene Ayuso, Ragunathan Padmashri, Christian Henneberger, Dmitri A. Rusakov, Alberto Alcázar, Ricardo S. Scott
The paper shows that brief ischemia causes transient calpain-dependent disruption of axon initial segments in hippocampal granule cells, which can be prevented by blocking Na+/Ca2+ exchanger activity.
bioRxiv · Dec 13, 2024 · PreprintNeuroscience