Dmitri A. Rusakov

NEURON-based platform that stochastically adds dendritic spines, astrocyte nanoprocesses and a dynamic extracellular space; example simulations show spines widen input-output range and myelin Kir4.1 sustains high-frequency conduction.

The paper shows that sensory experience increases glutamate release and strengthens synaptic connections in the barrel cortex, leading to changes in the functional connectome.

This study shows that focal loss of astrocytic Kir4.1 in the adult hippocampus causes seizures, spreading depolarizations, and postictal impairments.

The paper shows that astrocytic RNA editing via ADAR1 modulates immune responses to alpha-synuclein, contributing to neuroinflammation in Parkinson's disease.

The paper improves a GABA sensor, iGABASnFR2, with higher sensitivity and faster kinetics, enabling better in vivo imaging of GABAergic transmission.

The paper shows that brief ischemia causes transient calpain-dependent disruption of axon initial segments in hippocampal granule cells, which can be prevented by blocking Na+/Ca2+ exchanger activity.

The paper shows that volume-transmitted GABA waves drive epileptiform rhythms in hippocampal networks by elevating tonic GABAA receptor conductance across multiple cells.

This study uses hiPSCs with SNCA mutations to identify early molecular events in synucleinopathy, showing protein aggregation precedes functional impairments in midbrain dopaminergic neurons.

The paper shows that sensory-stimulation LTP increases synaptic fidelity while reducing excitation at thalamocortical connections, generating spatially intersecting glutamate discharges.

The paper shows that postsynaptic NMDA receptor-mediated K+ efflux reduces astrocytic glutamate uptake while enhancing presynaptic glutamate release.

The paper visualizes and quantifies GLT1 transporter dynamics on astrocytes, showing rapid recycling and identifying factors influencing its membrane turnover.

The paper shows that release probability increases with distance from the soma in CA3-CA1 synapses, enhancing signal transfer fidelity at higher frequencies.

This study shows that LTP induces astroglial withdrawal, increasing glutamate spillover and inter-synaptic communication.

The paper shows that extracellular GABA concentration modulates coincidence detection in excitatory circuits by affecting membrane shunting via GAT-1.

This paper develops a genetically encoded fluorescent sensor, iGABASnFR, to monitor GABA in vivo and demonstrates its use in tracking GABA dynamics in various neural contexts.

The paper uses multiplex imaging to simultaneously measure presynaptic Ca2+ and glutamate release at multiple synapses in situ.

This study uses multiplexed multiphoton imaging to examine the relationship between synaptic activity and astroglial responses in the intact brain, finding that astrocytic Ca2+ elevations often precede presynaptic Ca2+ signals.

The paper constructs a realistic multi-compartmental astrocyte model to explore its biophysical properties and uncover features inaccessible through empirical methods.