NeurosciencebioRxivPreprint
Xylazine is an agonist at kappa opioid receptors and exhibits sex-specific responses to naloxone administration
Madigan L. Bedard, Jackson G. Murray, Xi‐Ping Huang…·Zoé A. McElligott
This study shows xylazine acts as a kappa opioid receptor agonist and that naloxone induces withdrawal from xylazine and fentanyl/xylazine combinations, with greater sensitivity in females.
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