Human Herpesvirus 8 ORF57 protein is able to reduce TDP-43 pathology: Network analysis Identifies Interacting Pathways
Chelsea Joy Webber, Caroline N. Murphy, Alejandro Nico Rondón-Ortiz, Sophie J. F. van der Spek, Elena X. Kelly, Noah M. Lampl, Giulio Chiesa, Ahmad S. Khalil, Andrew Emili, Benjamin L. Wolozin
The paper shows that ORF57 from Human Herpesvirus 8 reduces TDP-43 aggregation and cell death by interacting with ISR components.
Human Molecular Genetics · Jul 28, 2023Peer-reviewedNeuroscience