Sophie J. F. van der Spek

Progressive Remodeling of Global Protein Interaction Networks in a Mouse Model of Tauopathy

The paper maps protein interaction network remodeling in a mouse tauopathy model using multi-omics and machine learning, identifying key complexes involved in early disease phenotypes.

Loss of age-associated increase in m6A-modified RNA contributes to GABAergic dysregulation in Alzheimer's disease

The paper shows that loss of age-related m6A RNA methylation in Alzheimer's disease brains is linked to GABAergic dysfunction and synaptic issues.

TIA1 Mediates Divergent Inflammatory Responses to Tauopathy in Microglia and Macrophages

This study shows TIA1 regulates divergent inflammatory responses in microglia and macrophages, reducing brain inflammation and tau pathology while increasing peripheral inflammation.

Human Herpesvirus 8 ORF57 protein is able to reduce TDP-43 pathology: Network analysis Identifies Interacting Pathways

The paper shows that ORF57 from Human Herpesvirus 8 reduces TDP-43 aggregation and cell death by interacting with ISR components.

Transcriptional diversity in synaptic gene sets is sufficient to discriminate cortical neuronal identity

The paper identifies synaptic gene sets that can discriminate cortical neuronal identities with the same power as all genes, revealing functional categories and compartments with cell type-specific expression.

β-amyloid-driven synaptic depression requires PDZ protein interaction at AMPA-receptor subunit GluA3

This study shows that β-amyloid oligomers cause synaptic depression by removing GluA3-containing AMPARs from synapses, requiring PDZ protein interaction.