Noah M. Lampl

Progressive Remodeling of Global Protein Interaction Networks in a Mouse Model of Tauopathy

The paper maps protein interaction network remodeling in a mouse tauopathy model using multi-omics and machine learning, identifying key complexes involved in early disease phenotypes.

Saturating variant analysis of TERC redefines the human telomerase reverse transcription mechanism

The paper functionally analyzes TERC variants to redefine the human telomerase reverse transcription mechanism, revealing eight templating residues and a hyperactive variant that lengthens telomeres.

Chemotherapeutic 6-thio-2-deoxyguanosine selectively targets and inhibits telomerase by inducing a non-productive telomere-bound telomerase complex

This study shows 6-thio-dG inhibits telomerase by forming a non-productive complex, affecting telomere maintenance in cancer cells.

Beyond Glycolysis: Aldolase A is a Novel Effector in Reelin Mediated Dendritic Development

This study identifies aldolase A as a novel Reelin effector involved in dendritic development, independent of its glycolytic function.

PANAMA enabled high sensitivity dual nanoflow LC/MS metabolomics and proteomics analysis

PANAMA enables high sensitivity joint metabolomics and proteomics analysis using nanoflow LC/MS without instrument duplication, improving resolution and detection sensitivity.

Human Herpesvirus 8 ORF57 protein is able to reduce TDP-43 pathology: Network analysis Identifies Interacting Pathways

The paper shows that ORF57 from Human Herpesvirus 8 reduces TDP-43 aggregation and cell death by interacting with ISR components.