Vagal Signaling Decline in Age-related Macular Degeneration Drives Spleen-Dependent Retinal Inflammation
Kaitryn E. Ronning, Christophe Roubeix, Caroline Nous, Sébastien Augustin, Frédéric Blond, Foteini Argyriou, Christopher Rue Molbech, Katalin Veres, Jesper Mehlsen, Marie Bak, Emmanuel L. Gautier, Henrik Toft Sørensen, Xavier Guillonneau, Cécile Delarasse, Torben Lykke Sørensen, Florian Sennlaub
This study shows that reduced vagal signaling increases AMD risk by promoting splenic monocyte infiltration into the retina, with splenectomy reversing these effects.
bioRxiv · Feb 23, 2026 · PreprintImmunology