The paper develops a microtissue-based platform to test antifibrotic drugs using retinal pigment epithelium cells, showing fibrotic phenotype induction and drug response.

bioRxiv · Jun 16, 2026 · PreprintCell Biology

A novel mouse model of hypertensive emergency with multiorgan microvascular disease implicating the VEGFA/sFlt-1 balance

Thibaut d’Izarny-Gargas, Imane Bensaada, Christophe Roubeix, Léa Guyonnet, Véronique Baudrie, Sarah Azancot, Pauline Maurissens, Léa Resmini, Arthur Lavigne, Christine Ibrahim, Léa Dionet, Anna Chipont, Carole Hénique, Philippe Bonnin, Xavier Guillonneau, , Pierre‐Louis Tharaux

This study develops a mouse model of hypertensive emergency with multiorgan microvascular disease and identifies dysregulated VEGFA/sFlt-1 signaling as a key driver.

bioRxiv · Mar 6, 2026 · PreprintPathology

Vagal Signaling Decline in Age-related Macular Degeneration Drives Spleen-Dependent Retinal Inflammation

Kaitryn E. Ronning, Christophe Roubeix, Caroline Nous, Sébastien Augustin, Frédéric Blond, Foteini Argyriou, Christopher Rue Molbech, Katalin Veres, Jesper Mehlsen, Marie Bak, Emmanuel L. Gautier, Henrik Toft Sørensen, Xavier Guillonneau, Cécile Delarasse, Torben Lykke Sørensen, Florian Sennlaub

This study shows that reduced vagal signaling increases AMD risk by promoting splenic monocyte infiltration into the retina, with splenectomy reversing these effects.

bioRxiv · Feb 23, 2026 · PreprintImmunology