Clostridioides difficile infection increases circulating p-cresol levels and dysregulates brain dopamine metabolism: linking gut-brain axis to autism and other neurologic disorders?
Akhil A. Vinithakumari, Piyush Padhi, Belen Hernandez, Susanne Je-Han Lin, Aaron Dunkerson-Kurzhumov, Lucas John Showman, Matthew W. Breitzman, Caroline Stokes, Yousuf Sulaiman, Chandra S. Tangudu, Deepa Ashwarya Kuttappan, Muhammed Shafeekh Muyyarikkandy, Gregory J. Phillips, Vellareddy Anantharam, Ann M. Perera, , Shankumar Mooyottu
This study shows C. difficile infection increases p-cresol and alters dopamine metabolism in mice, linking gut microbiota to neurodevelopmental disorders.
bioRxiv · Oct 22, 2021 · PreprintNeuroscience