Vellareddy Anantharam

Prokineticin-2 Upregulates GDNF in Astrocytes and Pharmacological Modulation of PK2 Receptors offers Neuroprotection in Experimental Models of Parkinson's Disease

This study shows that PK2 signaling increases GDNF in astrocytes and that modulating PK2 receptors protects neurons in Parkinson's disease models.

Mitochondrial Stress Disassembles Nuclear Architecture through Proteolytic Activation of PKCδ and Lamin B1 Phosphorylation in Neuronal Cells: Implications for Pathogenesis of Age-related Neurodegenerative Diseases

This study shows mitochondrial stress triggers PKCδ activation and Lamin B1 phosphorylation, leading to nuclear membrane damage and neuronal cell death in Parkinson's disease.

KCa3.1 Contributes to Neuroinflammation and Nigral Dopaminergic Neurodegeneration in Experimental models of Parkinson's Disease

This study shows that inhibiting KCa3.1 channels reduces neuroinflammation and dopaminergic neurodegeneration in Parkinson's disease models.

Rationally Designed PKD1 Activator Protects Against Neurodegeneration in Pre-clinical Models of Parkinson's Disease

The paper develops a rationally designed PKD1 activator peptide, AK-P4T, which protects against neurodegeneration in pre-clinical Parkinson's disease models.

Mitochondrial dysfunction Impairs the Nuclear Pore Complex in Parkinson's Disease Pathogenesis

The paper investigates how mitochondrial dysfunction affects the nuclear pore complex in Parkinson's disease by analyzing Nup expression and localization in dopaminergic neurons.

Epitranscriptomic Reader YTHDF2 Regulates SEK1(MAP2K4)-JNK-cJUN Inflammatory Signaling in Astrocytes during Neurotoxic Stress

This study shows YTHDF2 regulates inflammatory signaling in astrocytes during neurotoxic stress by modulating SEK1-JNK-cJUN pathway activation.

Clostridioides difficile infection increases circulating p-cresol levels and dysregulates brain dopamine metabolism: linking gut-brain axis to autism and other neurologic disorders?

This study shows C. difficile infection increases p-cresol and alters dopamine metabolism in mice, linking gut microbiota to neurodevelopmental disorders.

Characterization of Nonmotor Symptoms in the MitoPark Mouse Model of Parkinson's Disease

This study characterizes nonmotor symptoms in MitoPark mice, showing cognitive, olfactory, and anxiety-depressive deficits that respond to antidepressants.

Mitochondrial Dysfunction Induces Epigenetic Dysregulation by H3K27 Hyperacetylation to Perturb Active Enhancers in Parkinson’s Disease Models

This study shows that mitochondrial dysfunction in Parkinson’s disease models leads to H3K27 hyperacetylation, disrupting active enhancers and epigenetic regulation.