Structural and enzymatic divergence between human MDH isoforms underlies their specialized regulatory roles in metabolism
Christopher Berndsen, Angela J. Kayll, Ruhi Rahman, Jackson R Tester, Trip Beaver, Caroline Tuck, Sonja Neve-Hoversten, Lisa Gentile, Tamerat Mandanis, Joseph John Provost
This study compares human MDH1 and MDH2 isoforms to show structural and enzymatic differences that explain their distinct regulatory roles in metabolism.
bioRxiv · Jul 15, 2025 · PreprintBiochemistry