Christopher Berndsen

Functional Characterization of Arabidopsis α-Amylase3 (AMY3): Amylose Specificity and Structural Insights into Its Duplex Carbohydrate-Binding Module

This study characterizes Arabidopsis AMY3, showing it preferentially hydrolyzes amylose over amylopectin and identifies a unique duplex carbohydrate-binding module involved in dimerization.

Molecular Architecture of the human Citrate Synthase-Malate Dehydrogenase 2 metabolon

The paper provides structural evidence for the human Citrate Synthase-Malate Dehydrogenase 2 metabolon and shows its transient nature and non-specific interaction site.

Biophysical and enzymatic comparison of Bacillus safensis and Bacillus subtilis malate dehydrogenase (MDH) enzymes

The paper compares the biophysical and enzymatic properties of malate dehydrogenase from Bacillus safensis and Bacillus subtilis, revealing differences in thermal stability and enzymatic activity.

Structural and enzymatic divergence between human MDH isoforms underlies their specialized regulatory roles in metabolism

This study compares human MDH1 and MDH2 isoforms to show structural and enzymatic differences that explain their distinct regulatory roles in metabolism.

The pseudoenzyme β-amylase9 from Arabidopsis binds to and enhances the activity of α-amylase3: A possible mechanism to promote stress-induced starch degradation

This study identifies BAM9 as a pseudoenzyme that interacts with and activates AMY3 to enhance starch degradation under stress conditions.

Modeling of Epigenetic Modification-Induced Changes in CRX-dependent Genes cis-Regulatory Elements

The paper models how DNA methylation affects CRX binding to regulatory elements of RHO and PDE6B genes in human ocular tissues, showing inverse correlations and structural changes in DNA grooves.

Conformational locking of Ufm1 upon binding to the Ufm1-interacting sequence of Uba5

The paper investigates the interaction between Ufm1 and the UIS sequence of Uba5 using molecular dynamics simulations, revealing structural changes and functional roles in Ufm1 activation.