Cancer BiologyBloodPeer-reviewed
Harnessing the CD2 axis to broaden and enhance the efficacy of CAR T cell therapies
Alberto Carturan, Mathew G. Angelos, Puneeth Guruprasad…·Marco Ruella
This paper develops anti-CD2 CAR T-cells that overcome fratricide and improve efficacy by incorporating a PD-1:CD2 switch receptor to restore CD2 signaling.
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