Charting the transition from in vitro gliogenesis to the in vivo maturation of transplanted human glial progenitor cells
John N. Mariani, Steven J. Schanz, Benjamin Mansky, Xiaolu Wei, Carter C. Long, Devin Chandler-Militello, Nguyen P.T. Huynh, Steven A. Goldman
This study tracks the in vitro generation and in vivo differentiation of human glial progenitor cells using single-cell RNA and ATAC-seq, revealing how the host environment influences their maturation into astrocytes and oligodendrocytes.
bioRxiv · Apr 22, 2025 · PreprintNeuroscience