Author

Nguyen P.T. Huynh

University of CopenhagenORCID 0000-0002-7254-1645Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Assay:scRNA-seq· 4 Organism:human· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Research Focus:clustering· 2 Research Focus:differential expression· 2 Research Focus:gene regulatory network inference· 2 Approach:machine learning (classical)· 2

Frequent Co-Authors

Benjamin ManskyiD· 2 shared Farshid GuilakiD· 2 shared John N. MarianiiD· 2 shared Natalie H. KellyiD· 2 shared Steven A. GoldmaniD· 2 shared Steven J. SchanziD· 2 shared Carter C. Long· 1 shared Dakota B. KatziD· 1 shared

Activity by Year

2019-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 22 mutual co-author links

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2 shared papersNeuroscience

Benjamin ManskyORCID

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4 papers

Recent·Most cited

Histone hyperacetylation-linked upregulation of KRAB zinc finger proteins impedes glial differentiation in Huntington's disease

Peter Brøgger, John N. Mariani, Dennis Salinas, Benjamin Mansky, Steven J. Schanz, Nguyen P.T. Huynh, Rossana Foti, Steven A. Goldman

The paper identifies histone hyperacetylation and KZFP overexpression in HD glial progenitor cells as mechanisms impairing glial differentiation.

bioRxiv · Dec 2, 2025 · PreprintNeuroscience

Charting the transition from in vitro gliogenesis to the in vivo maturation of transplanted human glial progenitor cells

John N. Mariani, Steven J. Schanz, Benjamin Mansky, Xiaolu Wei, Carter C. Long, Devin Chandler-Militello, Nguyen P.T. Huynh, Steven A. Goldman

This study tracks the in vitro generation and in vivo differentiation of human glial progenitor cells using single-cell RNA and ATAC-seq, revealing how the host environment influences their maturation into astrocytes and oligodendrocytes.

bioRxiv · Apr 22, 2025 · PreprintNeuroscience

Single cell RNA-sequencing reveals cellular heterogeneity and trajectories of lineage specification during murine embryonic limb development

Natalie H. Kelly, Nguyen P.T. Huynh, Farshid Guilak

This study uses scRNA-seq to analyze murine hindlimb development, identifying cellular heterogeneity and trajectories of lineage specification across embryonic stages.

Matrix Biology · Dec 23, 2019Peer-reviewedMolecular Biology

Single Cell RNA Sequencing Reveals Heterogeneity of Human MSC Chondrogenesis: Lasso Regularized Logistic Regression to Identify Gene and Regulatory Signatures

Nguyen P.T. Huynh, Natalie H. Kelly, Dakota B. Katz, Minh Pham, Farshid Guilak

The paper uses scRNA-seq and lasso regularized logistic regression to identify gene and regulatory signatures in human MSC chondrogenesis, revealing subpopulations and their differentiation potential.

bioRxiv · Nov 25, 2019 · PreprintGenomics