Steven A. Goldman

This study identifies cell competition as a key driver of gliomagenesis by showing that pre-malignant OPCs outcompete wildtype cells, and inhibiting this process reduces tumor growth.

The paper identifies histone hyperacetylation and KZFP overexpression in HD glial progenitor cells as mechanisms impairing glial differentiation.

The paper describes engineering AAV5 capsids to target human glial progenitor cells and uses glymphatic delivery to achieve efficient brain-wide transduction with minimal off-target effects.

This study tracks the in vitro generation and in vivo differentiation of human glial progenitor cells using single-cell RNA and ATAC-seq, revealing how the host environment influences their maturation into astrocytes and oligodendrocytes.

This study shows glymphatic clearance is increased during sleep and anesthesia and reduced during wakefulness, with tracer dose adjustments needed for accurate comparison across brain states.

This study uses human-mouse chimeric brain models to investigate glial-neuronal and macroglial-microglial interactions, revealing key molecular mechanisms and dynamic cellular behaviors.

The paper profiles histone modifications in adult human CNS cells, revealing epigenetic memory of developmental programs in oligodendroglia.

The paper uses single-nucleus RNA-sequencing to compare non-enhancing and contrast-enhancing regions of high-grade gliomas, finding distinct cellular states and microenvironment features in NE regions.

The paper uses imaging and ultrastructural analysis to show that astrocytic engagement of synapses is impaired in a mouse model of Huntington disease, contributing to synaptic dysfunction and hyperexcitability.

The paper compares gene expression and stress responses in human and mouse astrocytes, finding conserved and divergent features that may explain differences in disease models.

This study shows human glial progenitor cells can remyelinate both congenitally and acutely demyelinated adult CNS regions, extending lifespan and restoring function in mouse models.