Steven J. Schanz

The paper identifies histone hyperacetylation and KZFP overexpression in HD glial progenitor cells as mechanisms impairing glial differentiation.

The paper describes engineering AAV5 capsids to target human glial progenitor cells and uses glymphatic delivery to achieve efficient brain-wide transduction with minimal off-target effects.

This study tracks the in vitro generation and in vivo differentiation of human glial progenitor cells using single-cell RNA and ATAC-seq, revealing how the host environment influences their maturation into astrocytes and oligodendrocytes.

This study shows human glial progenitor cells can remyelinate both congenitally and acutely demyelinated adult CNS regions, extending lifespan and restoring function in mouse models.