Identification of pan-cancer/testis genes and validation of therapeutic targeting in triple-negative breast cancer: Lin28a- and Siglece-based vaccination induces anti-tumor immunity and inhibits metastasis
Jason A. Carter, Bharati Matta, Jenna Battaglia, Carter C. Somerville, Benjamin D. Harris, Margaret LaPan, Gurinder S. Atwal, Betsy Jo Barnes
The paper identifies pan-cancer/testis genes and validates their use as therapeutic targets in triple-negative breast cancer through vaccination with Lin28a and Siglece antigens, showing reduced tumor growth and metastasis.
bioRxiv · May 9, 2023 · PreprintBioinformatics