Jason A. Carter

The DNAJB1-PRKACA Oncogenic Fusion Drives Stepwise Biliary and Pancreatic Carcinogenesis from Intraductal Precursor Lesions

This study develops a mouse model of DNAJB1-PRKACA fusion and shows it drives biliary and pancreatic carcinogenesis, with pre-invasive features and Slc16a14 as a biomarker for malignant transformation.

Identification of pan-cancer/testis genes and validation of therapeutic targeting in triple-negative breast cancer: Lin28a- and Siglece-based vaccination induces anti-tumor immunity and inhibits metastasis

The paper identifies pan-cancer/testis genes and validates their use as therapeutic targets in triple-negative breast cancer through vaccination with Lin28a and Siglece antigens, showing reduced tumor growth and metastasis.

T-cell receptor αβ chain pairing is associated with CD4+ and CD8+ lineage specification

The paper analyzes TCR {beta} chain pairing in human T-cells to determine its role in CD4+ and CD8+ lineage specification, finding that {beta} chain pairs are more informative than individual chains for lineage prediction.

Single-cell sequencing reveals αβ chain pairing shapes the T cell repertoire

This study uses single-cell sequencing to analyze T cell receptor pairing, finding non-random β chain associations and public clone sharing, which reduce T cell repertoire diversity.