Betsy Jo Barnes

This study identifies IRF5 as a critical driver of iHPC differentiation and MAS pathogenesis, showing it can be targeted pharmacologically.

The paper identifies a type I IFN-driven monocyte dysregulation and a MAS-associated CD8+ T cell population in macrophage activation syndrome using bulk and single-cell RNA sequencing.

This study shows that pathogenic Ruminococcus gnavus strains in the gut drive platelet activation and thromboinflammation in lupus nephritis, with antibodies against its lipoglycan as a potential biomarker.

This study identifies IRF5 as a key regulator of T cell effector function through mTORC1 signaling, glutamine metabolism, and post-transcriptional control following TCR activation.

The paper identifies pan-cancer/testis genes and validates their use as therapeutic targets in triple-negative breast cancer through vaccination with Lin28a and Siglece antigens, showing reduced tumor growth and metastasis.