Trehalose dimycolate inhibits phagosome maturation and promotes intracellular M. tuberculosis growth via noncanonical SNARE interaction
Carolina Santamaria, Kyle J. Biegas, Pamelia N. Lim, Jessica Cabral, Christi Y. Kim, James R. Lee, Ishani V. Gaidhane, Casey Papson, Kyla Gomard-Henshaw, Alissa C. Rothchild, Benjamin M. Swarts, M. Sloan Siegrist
This study identifies TDM's mechanism of inhibiting phagosome maturation by interacting with SNARE proteins, promoting M. tuberculosis growth.
Proceedings of the National Academy of Sciences · May 12, 2025Peer-reviewedMicrobiology