A Kalirin Missense Mutation Enhances Dendritic RhoA Signaling and Leads to Regression of Cortical Dendritic Arbors Across Development
Melanie J. Grubisha, Tao Sun, Leanna R. Eisenman, Susan L. Erickson, Shinnyi Chou, Cassandra Helmer, Melody T. Trudgen, Ying Ding, Gregg E. Homanics, Peter Penzes, Zachary P. Wills, Robert A. Sweet
This paper shows a Kalirin mutation enhances RhoA signaling, causing dendritic regression in mice during adolescence, linking it to schizophrenia-like structural impairments.
Proceedings of the National Academy of Sciences · Nov 30, 2021Peer-reviewedNeuroscience