Robert A. Sweet

Genetic correlation analysis identifies TMEM106B, ACE, and ERC2 as genetic loci shared between Alzheimer's disease and primary psychiatric disorders

A Key Regulator of Dendritic Morphology in Supragranular Neocortex Impacts Mismatch Negativity

This study investigates how a genetic mutation affecting cytoskeletal structure in mice impacts mismatch negativity, a biomarker of sensory integration, and links structural and functional deficits in supragranular neocortex.

Proteomic analysis in Alzheimer's disease with psychosis reveals a shared AD proteomic landscape and a separate molecular signature of postsynaptic density disruption

This study identifies a shared proteomic profile in Alzheimer's disease with and without psychosis and a separate molecular signature linked to postsynaptic density disruption.

Compensatory Plasticity Defines a Vulnerable Neuronal State in Alzheimers Disease with Psychosis

The paper identifies transcriptional changes in upper-layer cortical pyramidal neurons in Alzheimer's disease with psychosis, linking them to network dysfunction and vulnerability.

Missense and Loss of Function Variants at GWAS Loci in Familial Alzheimer's Disease

The paper examines rare missense and loss of function variants in GWAS loci for Alzheimer's disease across families, finding that many families lack identifiable variants beyond APOE-e4.

Terminal type-specific cannabinoid CB1 receptor alterations in patients with schizophrenia: a pilot study

This study examines CB1R levels in excitatory and inhibitory boutons in schizophrenia patients, finding increased CB1R in excitatory boutons and decreased in inhibitory ones, suggesting altered neurotransmission balance.

CACNB4 overexpression decreases dendritic spine density in sex-specific manner

This study shows that overexpressing CACNB4 reduces small dendritic spine density in female mice but not males, linked to sex differences in the {beta}4 interactome.

A Kalirin Missense Mutation Enhances Dendritic RhoA Signaling and Leads to Regression of Cortical Dendritic Arbors Across Development

This paper shows a Kalirin mutation enhances RhoA signaling, causing dendritic regression in mice during adolescence, linking it to schizophrenia-like structural impairments.

MAP2 is differentially phosphorylated in schizophrenia, altering its function

This study identifies MAP2 phosphorylation changes in schizophrenia, linking them to neuronal structure and synaptic function impairments through phosphoproteomics and transgenic mouse models.

Synaptic Proteome Alterations in the Primary Auditory Cortex of Schizophrenia

This study identifies synaptic proteome alterations in the primary auditory cortex of schizophrenia patients, showing coordinated changes in postsynaptic proteins not explained by global protein levels or confounding factors.