Gregg E. Homanics

This study shows disrupting astrocyte molecular rhythms in the nucleus accumbens increases binge-like drinking in mice without affecting other behaviors.

This study shows that preconception ethanol exposure affects offspring transcriptomes differently based on parent, sex, and tissue, indicating metabolic and immune issues.

This study shows that deleting Malat1 reduces alcohol consumption in female mice but not males, suggesting a sex-specific role in alcohol use disorder.

This study shows that PSEN1 mutant marmoset fibroblasts exhibit multi-omic signatures similar to Alzheimer's disease in humans, highlighting sex-specific differences and disease-relevant pathways.

This study shows that Prosapip1 in the dorsal hippocampus is essential for synaptic protein localization, long-term potentiation, and spatial memory.

This study investigates whether ethanol's interaction with BK channel α subunit residue K361 mediates behavioral responses to alcohol in mice, finding no significant effects on ethanol-related behaviors or consumption.

This study investigates the role of mGlu2 deletion in Emx1-lineage neurons on behavioral flexibility in mice, finding no significant impact on drug consumption predisposition.

This paper shows a Kalirin mutation enhances RhoA signaling, causing dendritic regression in mice during adolescence, linking it to schizophrenia-like structural impairments.

The paper identifies a Gabra2 variant that increases methamphetamine sensitivity using QTL analysis in mice and validates it with CRISPR correction.

This study identifies Gabra2 as a genetic modifier of Dravet syndrome in mice by showing that a deletion in Gabra2 worsens seizure and survival phenotypes in Scn1a+/- mice, which is reversed by repairing the deletion.

This study identifies MAP2 phosphorylation changes in schizophrenia, linking them to neuronal structure and synaptic function impairments through phosphoproteomics and transgenic mouse models.

This paper introduces CRISPy TAKO, a CRISPR/Cas9 method to generate homozygous knockout mice in one generation, validated using MyD88-/- mice showing expected ethanol-related behavioral changes.

The paper identifies a functional non-coding variant in the GABRA2 gene of the C57BL/6J mouse strain, showing its impact on Gabra2 expression and implications for neuroscience research.