Interpreting and Validating a Deep Learning Model Predictive of Spatial Morphologic-Molecular Patterns in Lung Adenocarcinoma, Using Ground Truth Immunohistochemistry
Vibha R Rao, Adrienne A. Workman, Scott M. Palisoul, Cassandra J Limoge, Louis Joseph Vaickus, George J. Zanazzi, Liang Lu, Xiaoying Liu, Shrey Sukhadia
XpressO-Lung predicts spatial gene expression patterns in lung adenocarcinoma using histopathology images, validated against immunohistochemistry, showing strong concordance with known morphologic features.
bioRxiv · Apr 23, 2026 · PreprintPathology